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卵巢癌(Ovarian Cancer)发病率较高,占妇科肿瘤发病之首,恶性程度较高,大多数发现于晚期,5年生存率仅为30％左右。而CA125是与上皮细胞型卵巢癌相伴随的表面抗原,检测血清中CA125对卵巢癌病人的手术治疗范围、术后复发及用药等问题均有指导意义。本文利用干扰素-α(interferon IFN)对体外人工培养的两株卵巢细胞系SKOV3及3AO表达CA125进行诱导调节,检测其浓度变化。旨在探讨IFN-α对卵巢癌可能的治疗作用。
Ovarian cancer (Ovarian Cancer) higher incidence, accounting for the incidence of gynecologic oncology, higher malignant, most found in late, 5-year survival rate of only about 30%. CA125 is associated with epithelial ovarian cancer surface antigen, the detection of serum CA125 in patients with ovarian cancer surgical treatment range, postoperative recurrence and medication and other issues are instructive. In this paper, interferon-α (interferon IFN) on cultured in vitro two ovarian cell lines SKOV3 and 3AO expression CA125 induced regulation, to detect the concentration changes. To investigate the possible therapeutic effect of IFN-α on ovarian cancer.