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普遍认为樟柳碱等M胆碱受体拮抗剂明显阻抑动物及人的学习和记忆。很多作者报道它有干扰学习、破坏记忆的作用,并用于记忆障碍模型。我们研究发现樟柳碱对学习记忆有双相作用,0.5mg/kg以下有促进学习记忆。迷宫法测定对小鼠记忆的获得、巩固及再现三个过程均有作用,尤以记忆的获得更为突出,达标所需训练次数对照组为44±SD5次,给药组仅需10±2次。但在2.5mg/kg大剂量下则影响学习能力,特别是获得阶
It is generally believed that the anisodine and other M cholinergic receptor antagonists significantly inhibit animal and human learning and memory. Many authors report that it interferes with learning and destroys memory and is used in memory impairment models. We found that anisodine has a biphasic effect on learning and memory, and 0.5 mg/kg or less promotes learning and memory. The maze test had effects on the acquisition, consolidation, and reproduction of memory in mice. In particular, the acquisition of memory was more prominent. The number of training required for reaching the target was 44±SD 5 times for the control group and only 10±2 for the administration group. Times. However, at a high dose of 2.5 mg/kg, it affects learning ability, especially gaining