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环孢霉素A(CsA)肾毒性的作用机理至今还不十分明确,而反应性氧代谢产物(ROM)与许多肾脏疾病有关。将Wistar大鼠分别给CsA三种剂量12.5、25、50mg·kg(-1)/d灌胃7天,大鼠出现急性肾功能不全,血肌酐、血清及肾皮质匀浆丙二醛显著升高,而肾皮质匀浆超氧化物歧化酶活性及全血谷胱甘肽过氧化物酶活性下降。在人参总皂甙及去铁敏预防组中,上述指标与正常组比差异不显著,提示ROM的增加及肾脏抗氧化能力的下降参与了CsA所致的急性肾毒性作用,而人参总皂甙、去铁敏具有预防作用。
The mechanism of action of cyclosporine A (CsA) nephrotoxicity is not yet fully understood, and reactive oxygen metabolites (ROMs) are associated with many kidney diseases. Wistar rats were given CsA three doses of 12.5,25,50 mg kg / d gavage for 7 days, rats with acute renal insufficiency, serum creatinine, serum and renal cortical plasma malondialdehyde Significantly increased, while renal cortical superoxide dismutase activity and whole blood glutathione peroxidase activity decreased. In ginsenosides and deferoxamine prophylaxis group, the above indexes were not significantly different from those in normal group, suggesting that the increase of ROM and the decrease of renal antioxidant capacity were involved in the acute nephrotoxicity induced by CsA, whereas the total ginsenosides, Minmin has a preventive effect.