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采用硅烷化等方法合成 3种新的含有大官能团和长烷基链的 β-环糊精衍生物固定相 :七 (2 ,3- O-二苄基 - 6- O-叔丁基二甲基硅基 ) - β- CD、七 (2 ,3- O-二苄基 - 6- O-十二烷基 ) -β- CD、七 (2 ,3- O-二乙酰基 - 6- O-十二烷基 ) -β- CD,并考察了该固定相的气相色谱性能 .这些固定相均具有较好的成膜性 ,较高的柱效 ,对难分离的芳香族位置异构体二甲苯、甲酚等有很好的分离效果 .烷基链长的增加和大官能团的引入改变了环糊精的空腔结构 ;环糊精上取代基的大小、极性、形状与客体分子的 π- π相互作用等对于客体分子的识别起着关键的作用
Three kinds of β-cyclodextrin derivatives with large functional groups and long alkyl chains were synthesized by the methods of silanization and the like. The stationary phases were: (2,3-O-dibenzyl-6-O- (2, 3-O-dibenzyl-6-O-dodecyl) -β-CD, -dodecyl) -β-CD, and the gas chromatographic properties of the stationary phase were investigated.These stationary phases have good film-forming properties, high column efficiency, the separation of the aromatic isomer Xylene, cresol, etc. The increase of alkyl chain length and the introduction of large functional groups have changed the cavity structure of cyclodextrins. The size, polarity, shape of the substituents on the cyclodextrin and guest molecules The π-π interaction plays a key role in the identification of guest molecules