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活性氧等自由基对机体可以影响许多生理和病理的过程 ,并认为在诱发某些疾病的机制上起着关键作用。本工作主要以半导体激光取代氦氖激光 ,体外穴位外照射取代血管内照射 ( ILIB)以观察激光对体内SOD、LPO( MDA)、GSH及 GSH-PX的影响。实验结果提示 :半导体激光 ( 650 nm,1 0～ 1 5m W,CW)照射人体“扶突”穴位后 ,可以即刻非常显著地提高血清 SOD的活性 ( P<0 .0 0 5)。这将有效地即刻提高机体清除氧自由基的能力 ,改进当前的临床治疗方法 (血管内照射 )以及免除患者的血管损伤 ,细菌感染等等的作用 ,再加仪器更轻巧 ,故在临床应用上具有很重要的应用价值。在过氧化脂质 LPO( MDA)方面 ,虽亦见有相应减少的倾向 ,但不显著。在 GSH及 GSH-PX的抗氧化体系中 ,激光对它影响似乎不大。本工作还对家兔进行了模拟血管内照射的观察 ,在 SOD、LPO方面亦有类似倾向 ,但均未达显著性差异。可能与方法及剂量等因素有关。
Radicals such as reactive oxygen species can affect many physiological and pathological processes in the body and are believed to play a key role in the mechanisms that induce certain diseases. The main work of this work is to replace the He-Ne laser with a semiconductor laser, and to observe the effect of laser on SOD, LPO (MDA), GSH and GSH-PX in vivo by replacing the intravascular irradiation (ILIB) with external acupoint irradiation. The experimental results indicate that the serum SOD activity can be instantly and remarkably improved immediately after the semiconductor laser (650 nm, 10 ~ 15 mW, CW) irradiates the “Fuzhu” acupoints in the human body (P <0.05). This will effectively improve the ability of the body to scavenge oxygen free radicals immediately, improve the current clinical treatment (intravascular irradiation) and the role of eliminating vascular damage, bacterial infection and the like of the patient, plus the more compact instrument, so in clinical application Has very important application value. LPO (lipid peroxidation), although there is also a corresponding tendency to reduce, but not significant. In GSH and GSH-PX antioxidant system, the laser does not seem to influence on it. In this work, rabbits were also observed the simulation of intravascular irradiation, SOD, LPO also have similar tendencies, but did not reach significant differences. May be related to methods and dosage and other factors.