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目的 :探讨补气通络方对周围神经损伤的治疗效果 ,揭示其作用机理 ,为临床用药提供新的方法和途径。方法 :实验通过清洁级 Wistar大鼠 4 8只 ,行右坐骨神经横形切断后即刻原位吻合术造模 ,制成神经损伤模型 ,造模成功后随机分成 4组 ,每组 1 2只。用补气通络胶囊剂和注射剂治疗作 2个观察组 ,设立两个同期对照组 :维生素 B1 +B6的阳性对照组和空白对照组 ,经过造模后 4、8、1 2周 ,每组随机抽取 4只大鼠 ,取其双侧小腿三头肌称量湿重 ,以肌重及恢复程度作为观测指标 ,判断神经的修复情况。结果 :补气通络方两个治疗组的小腿三头肌湿重及其恢复率比维生素 B1 +B6 组恢复快 (P<0 .0 5) ;比空白组差异非常显著 (P<0 .0 1 ) ;维生素 B1 +B6 组的恢复也明显快于空白组 (P<0 .0 5)。结论 :补气通络方对周围神经损伤后的恢复有促进作用 ,有临床开发利用价值。
Objective: To explore the therapeutic effect of Buqi Tongluo on peripheral nerve injury, reveal its mechanism of action, and provide new methods and approaches for clinical drug use. Methods : 48 Wistar rats of clean grade were used to make a model of in situ anastomosis immediately after the right sciatic nerve was cut transversely to make a nerve injury model. After successful modeling, the rats were randomly divided into 4 groups with 12 rats in each group. Two observation groups were treated with Buqi Tongluo capsule and injection. Two control groups were established: a positive control group of vitamin B1 + B6 and a blank control group. After 4, 8, and 12 weeks after modeling, each group Four rats were randomly selected and the wet weights of the bilateral triceps brachii muscles were measured. The weight of the muscles and the degree of recovery were used as observation indexes to judge the repair of the nerves. Results: The weight and recovery rate of triceps brachii muscle in the two treatment groups of Buqi Tongluo group was faster than that of vitamin B1 + B6 group (P<0.05), and it was significantly different from the blank group (P<0. 0 1 ) ; The recovery of vitamin B1 + B6 group was also significantly faster than that of the blank group (P < 0.05). Conclusion : Buqi Tongluo can promote the recovery of peripheral nerve injury and has clinical development and utilization value.