自神经肽Ｙ（ＮＰＹ）从猪脑中得以分离以来， 人们对ＮＰＹ在中枢神经系统中的作用进行了不断的研究，并发现ＮＰＹ及其三种受体亚型Ｙ１，Ｙ２，Ｙ３ 在中枢神经系统中有丰富的分布， ＮＰＹ的三种受体亚型相互协调、相互制约、精细地调节着血压的变化。本文介绍了ＮＰＹ受体亚型功能异常在高血压发病机理中的重要地位， 展示了ＮＰＹ受体拮抗剂作为新一代抗高血压药物的良好前景 Since the release of neuropeptide Y (NPY) from porcine brain, the role of NPY in the central nervous system has been continuously studied and found that NPY and its three receptor subtypes, Y1, Y2, and Y3, The system is rich in distribution, NPY receptor subtype coordination with each other, mutual restraint, fine-tune the changes in blood pressure. This article describes the important role of NPY receptor subtypes dysfunction in the pathogenesis of hypertension and demonstrates the promising future of NPY receptor antagonists as a new generation of antihypertensives