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目的观察甘精胰岛素联合瑞格列奈治疗2型糖尿病的临床效果。方法选取2型糖尿病患者74例,随机分为观察组和对照组各37例。对照组予预混胰岛素治疗,观察组予甘精胰岛素联合瑞格列奈治疗,观察2组临床指标及症状积分变化。结果治疗后2组各项指标均优于治疗前,且观察组空腹血糖、餐后2h血糖、体质量指数与糖化血红蛋白均低于对照组,ISI优于对照组(P<0.05)。治疗后2组症状积分较治疗前比较差异有统计学意义(t=3.35,P<0.05),且观察组优于对照组。结论采用甘精胰岛素联合瑞格列奈治疗2型糖尿病,治疗效果显著,可明显改善患者症状,且不良反应小,值得临床推广应用。
Objective To observe the clinical effect of insulin glargine combined with repaglinide on type 2 diabetes mellitus. Methods 74 patients with type 2 diabetes mellitus were randomly divided into observation group and control group, 37 cases each. The control group was given premixed insulin therapy. The observation group was treated with glargine and repaglinide. The changes of clinical indexes and symptom scores were observed in the two groups. Results After treatment, the indexes of two groups were better than those before treatment. The fasting blood glucose, 2h postprandial blood glucose, body mass index and HbA1c in the observation group were lower than those in the control group. ISI was better than the control group (P <0.05). After treatment, the scores of symptom scores in two groups were significantly different from those before treatment (t = 3.35, P <0.05), and the observation group was superior to the control group. Conclusion Glargine and repaglinide are effective in treating type 2 diabetes mellitus with obvious curative effect. It can significantly improve the symptoms of patients with less adverse reactions and is worthy of clinical application.