论文部分内容阅读
采用小鼠氨水引咳法和酚红法研究了金耳子实体浸液的镇咳祛痰作用，发现125mg／20g·d剂量，PO给药10d，可延长小鼠咳嗽发生的潜伏期，促进呼吸道分泌作用，增加酚红排出量，对乙酰胆碱引起的豚鼠气管螺旋条收缩具有松弛抬抗作用。采用四氧嘧啶致SD大鼠高血糖模型观察了金耳子实体浸液对其影响，结果按5g／kg生药等量的剂量一次性给药，在0～120min内大鼠的基础血糖没有升高，略有下降，继续按体重5g／kg·d、6g／kg·d二种剂量PO给药21d，发现可降低高血糖大鼠血清葡萄糖和胆固醇水平，组间差异显著。综合结果可以提示，预防性服用金耳子实体浸液有助于实验动物的镇咳祛痰，使致痉的气管松弛。连续服用对四氧嘧啶所致SD大鼠高血糖模型具有显著的降糖作用。
The antitussive and expectorant effects of Jinhe fruiting body extracts were studied using mouse ammonia coughing method and phenol red method. It was found that 125 mg/20 g·d dose and PO administration for 10 d prolonged the incubation period of cough in mice and promoted the respiratory tract. The secretory effect increased phenol red output and had relaxing effect on acetylcholine-induced contraction of the guinea pig tracheal spiral strips. Allergic model of SD rats induced by alloxan-induced hyperglycemia was used to observe the effect of Jinling fruiting body immersion on the dosage of 5g/kg crude drug. The basal blood glucose of rats was not increased within 0-120min. High, slightly decreased, and continued to be administered for 21 days in two doses of 5 g/kg·d and 6 g/kg·d PO, and it was found that serum glucose and cholesterol levels in hyperglycemic rats could be reduced, and there was a significant difference between groups. The comprehensive results can suggest that prophylactic administration of golden ear fruit priming solution helps the antitussive and sputum of the experimental animals, and relaxes the trachea that causes paralysis. Continuous administration of alloxan-induced hyperglycemia in SD rats has a significant hypoglycemic effect.