本文主要报导在三年强化性合并化疗方案中加以预防性鞘内间歇注射甲氨喋呤(MTX)的效果。75例年龄15岁以下的急性淋巴性白血病患儿采用综合性化疗方案(L-2)及鞘内注射 MTX 治疗,结果除1例在诱导期间死于败血症外,所有患儿都获得缓解。有3例于缓解初期感染肺炎和肝炎而死亡,1例失去随访,其余70例中,19例完全缓解后复发,最长缓解期为44月。复发的主要部位为:3例 This article reports on the effectiveness of prophylactic intrathecal methotrexate (MTX) in three years of intensive chemotherapy. Seventy-five children aged 15 years or younger with acute lymphoblastic leukemia received a comprehensive chemotherapy regimen (L-2) and intrathecal injection of MTX. All but one patient died of sepsis during the induction period. Three patients died of remission of initial infection pneumonia and hepatitis and one patient lost follow-up. Of the remaining 70 patients, 19 relapsed after complete remission, and the longest remission period was 44 months. The main part of recurrence is: 3 cases