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目的:观察通腑益气汤联合西药治疗重症脓毒症患者的临床疗效,并探讨其干预机制。方法:将135例脓毒症患者随机分为对照组58例,治疗组59例。对照组给予西医常规治疗,治疗组在上述治疗的基础上加用通腑益气汤治疗。28天后观察患者APACHII评分,血清肿瘤坏死因子α(TNFα)、脑钠肽(BNP)、血清降钙素原(PCT)、白细胞介素-6(IL-6)的水平变化,并进行疗效比较。结果:2组治疗后APACH II评分下降,血清TNFα、BNP、PCT、IL-6水平与本组治疗前比较差异有统计学意义;治疗组治疗后血清TNFα、BNP、PCT、IL-6水平与对照组比较差异有统计学意义。结论:通腑益气汤可以明显降低患者APACH II评分,降低血清TNFα、BNP、PCT、IL-6水平,保护胃肠黏膜屏障,促进血液循环,改善患者脓毒症症状。
Objective: To observe the clinical efficacy of Tongfu Yiqi Decoction combined with western medicine in the treatment of severe sepsis and to explore its intervention mechanism. Methods: Seventy-five patients with sepsis were randomly divided into control group (58 cases) and treatment group (59 cases). The control group was given routine treatment of Western medicine, and the treatment group was treated with Tongfu Yiqi Decoction on the basis of the above treatment. After 28 days, APACHII score, serum TNF-α, BNP, PCT and IL-6 levels were observed and compared. . Results: The APACH II scores decreased, the levels of TNFα, BNP, PCT and IL-6 in the two groups were significantly different from those before treatment in both groups. The levels of TNFα, BNP, PCT and IL-6 in the treatment group The difference between the control group was statistically significant. Conclusion: Tongfu Yiqi Decoction can significantly reduce APACH II score, decrease serum TNFα, BNP, PCT, IL-6 levels, protect the gastrointestinal mucosal barrier, promote blood circulation and improve the symptoms of sepsis.