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目的:优选归辛胶囊中当归、川芎的提取工艺。方法:以阿魏酸、川芎嗪提取率为考察指标,用高效液相色谱法进行测定。采用正交试验与比较试验相结合的方法,对提取工艺进行优选。结果:提取次数对考察指标具有显著性影响。结论:确定归辛胶囊的最佳提取工艺为:加8倍量的70%乙醇,回流提取3次,每次2h。
Objective: To optimize the extraction process of Angelica sinensis and Rhizoma Chuanxiong in Guixin capsule. Methods: The extraction rate of ferulic acid and tetramethylpyrazine was taken as the index, and it was determined by high performance liquid chromatography. Using the combination of orthogonal test and comparative test, the extraction process is optimized. Results: The number of extractions has a significant effect on the inspection index. Conclusion: The optimal extraction process for the determination of Guixin capsules is: adding 8 times of 70% ethanol and refluxing 3 times for 2 hours.