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目的分析血清凝血酶敏感蛋白1(TSP-1)、血管内皮生长因子(VEGF)水平对原发性肝癌早期诊断的价值。方法选择我院收治的85例原发性肝癌患者将其作为实验组,并选择同期健康体检者40例作为对照组。选择酶联免疫吸附试验来对研究对象的血清TSP-1、VEGF水平进行测定,观察分析测定结果。结果实验组患者的血清TSP-1水平显著低于对照组(P<0.05),Ⅲ期患者的血清TSP-1水平显著低于Ⅰ期患者、Ⅱ期患者(P<0.05),Ⅰ期患者和Ⅱ期患者的血清TPS-1水平比较差异无统计学意义(P>0.05)。Ⅲ期患者的血清VEGF水平与Ⅰ期患者、Ⅱ期患者、对照组相比差异有统计学意义(P<0.05)。结论在对原发性肝癌进行早期诊断时,TSP-1具有非常重要的作用,而VEGF的早期诊断价值却比较有限。
Objective To analyze the value of serum thrombospondin 1 (TSP-1) and vascular endothelial growth factor (VEGF) in the early diagnosis of primary liver cancer. Methods Eighty-five patients with primary liver cancer admitted to our hospital were selected as the experimental group and 40 healthy subjects were selected as the control group. Select the enzyme-linked immunosorbent assay to test the serum TSP-1, VEGF levels were measured, the results observed and analyzed. Results The level of serum TSP-1 in the experimental group was significantly lower than that in the control group (P <0.05). The serum level of TSP-1 in stage Ⅲ patients was significantly lower than that in stage Ⅰ patients and stage Ⅱ patients (P0.05) The level of serum TPS-1 in patients with stage II was no significant difference (P> 0.05). The level of serum VEGF in stage Ⅲ patients was significantly higher than that in stage Ⅰ patients, stage Ⅱ patients and control group (P <0.05). Conclusion TSP-1 plays a very important role in the early diagnosis of primary liver cancer. However, the value of early diagnosis of VEGF is rather limited.