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目的:探讨绍兴地区成年女性高危型人乳头瘤病毒(HPV)的感染情况及其与年龄的关系,以探讨高危型HPV感染的临床意义。方法:以核酸分子快速杂交仪为平台,利用导流杂交技术同时检测15种高危亚型,用统计软件分析结果。结果:576例女性标本中,检测到高危型人乳头瘤病毒标本172例,阳性率为29.86%。高危亚型主要以HPV16、HPV52、HPV58、HPV31、HPV18等为主。阳性标本中,单一感染122例(70.93%),二重感染34例(19.78%),三重及以上感染16例(9.3%)。单一感染主要以HPV16、HPV58、HPV52为主;多重感染中以HPV52合并HPV16、58的感染最为多见。在年龄组中,筛查人群以21岁～40岁的妇女为主,41岁以后检测人数骤然减少。HPV感染高峰出现在21岁～25岁,检测阳性率远高于平均水平29.86%。结论:绍兴地区女性宫颈高危型HPV感染率较高,开展各型HPV检测对于HPV感染和子宫颈癌的诊断、治疗具有重要意义。
Objective: To investigate the infection status of high risk human papillomavirus (HPV) in adult women and its relationship with age in Shaoxing region so as to explore the clinical significance of high risk HPV infection. Methods: Rapid hybridization of nucleic acid as a platform, the use of flow-through hybridization detection of 15 high-risk subtypes at the same time, with statistical software to analyze the results. Results: Of the 576 female specimens, 172 cases of high-risk human papilloma virus were detected, the positive rate was 29.86%. High-risk subtype mainly HPV16, HPV52, HPV58, HPV31, HPV18-based. In positive samples, 122 cases (70.93%) were single infection, 34 cases (19.78%) were infected by double infection and 16 cases (9.3%) were infected by triple infection or more. Single infection mainly HPV16, HPV58, HPV52-based; multiple infections with HPV52 HPV16,58 infections most common. In the age group, the screening population is dominated by women between the ages of 21 and 40, and the number of tests after the age of 41 has dropped dramatically. The peak of HPV infection occurred in 21 years old to 25 years old, and the detection positive rate was much higher than the average level of 29.86%. Conclusion: The prevalence of high-risk cervical HPV infection in Shaoxing women is high. It is of great significance to carry out various types of HPV testing for the diagnosis and treatment of HPV infection and cervical cancer.