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目的检测凋亡蛋白酶活化因子(Apaf-1)在基底细胞样乳腺癌(BLBC)中的表达,分析Apaf-1与BLBC临床病理特征的关系。方法采用免疫组化方法检测43例BLBC、57例non-BLBC和60例癌旁正常乳腺组织中Apaf-1蛋白的表达。结果免疫组化检测结果显示,在BLBC及non-BLBC中Apaf-1的表达的阳性率分别为23.26%和49.12%,明显低于癌旁正常乳腺组织的75.00%,差异均有统计学意义(P<0.05);Apaf-1的表达与患者年龄无关,与BLBC淋巴结转移、肿瘤大小及临床分期负相关(P<0.05)。结论 BLBC组织低表达Apaf-1,Apaf-1可能与BLBC的发生、发展密切相关。
Objective To detect the expression of Apaf-1 in basal-like breast cancer (BLBC) and to analyze the relationship between Apaf-1 and clinicopathological features of BLBC. Methods Immunohistochemistry was used to detect the expression of Apaf-1 in 43 cases of BLBC, 57 cases of non-BLBC and 60 cases of normal breast tissues. Results The results of immunohistochemistry showed that the positive rates of Apaf-1 expression in BLBC and non-BLBC were 23.26% and 49.12%, respectively, which were significantly lower than those in normal breast tissues (75.00%), the differences were statistically significant ( P <0.05). The expression of Apaf-1 was not related to patient’s age, but negatively correlated with lymph node metastasis, tumor size and clinical stage (P <0.05). Conclusion The low expression of Apaf-1 and Apaf-1 in BLBC may be closely related to the occurrence and development of BLBC.