论文部分内容阅读
目的观察奥扎格雷钠联合甲钴胺治疗糖尿病周围神经病变(DPN)的临床疗效。方法80例糖尿病周围神经病变患者随机分为治疗组和对照组各40例。对照组给予甲钴胺500μg,肌肉注射,隔日1次,治疗组在对照组基础上给予奥扎格雷钠氯化钠注射液250m l,80mg,静脉滴注,每日1次,连用15d。分别测定两组治疗前后疗效和患侧腓总神经、胫神经运动传导速度。结果治疗组总有效率92.5%,对照组总有效率72.5%,两组患者治疗后正中神经、腓神经的感觉传导速度(SNCY)均有不同程度改善,以治疗组改善最为明显,两组总有效率和SNCY比较差异有统计学意义(P<0.05)。结论奥扎格雷钠联合甲钴胺治疗对DPN有良好的治疗效果。
Objective To observe the clinical efficacy of sodium ozagrel combined with mecobalamin in the treatment of diabetic peripheral neuropathy (DPN). Methods 80 patients with diabetic peripheral neuropathy were randomly divided into treatment group and control group of 40 cases. The control group was given methylcobalamin 500μg, intramuscular injection every other day, the treatment group was given Ozagrel sodium and sodium chloride injection on the basis of 250mg, 80mg, intravenous infusion once daily for 15d. The curative effect of the two groups before and after treatment and the velocity of motor and tibial nerve conduction in the affected side were measured respectively. Results The total effective rate was 92.5% in the treatment group and 72.5% in the control group. The sensory conduction velocity (SNCY) of the median nerve and the peroneal nerve in both groups improved to some extent after treatment, and the improvement was most obvious in the treatment group. Efficacy and SNCY difference was statistically significant (P <0.05). Conclusion Ozagrel combined with mecobalamin has good therapeutic effect on DPN.