1970—1971年期间,美国西南肿瘤化疗研究组(SWCCSG)对阿霉素及抗黑瘤(Dic)进行第Ⅱ期的研究,已证实这两个药物对软组织及骨肉瘤的病人有一定的疗效。表1是文献的总结,阿霉素有约27%的反应率,而抗黑瘤有15%的反应率。1971年南方研究院已开始研究并提示阿霉素及抗黑瘤的联合治疗,尤其在足量时,比单 During the period from 1970 to 1971, the SWCCSG conducted a phase II study of adriamycin and anti-melanoma (Dic). It has been demonstrated that these two drugs have a certain effect on soft tissue and osteosarcoma patients. . Table 1 is a summary of the literature, doxorubicin has a response rate of about 27%, and anti-melanomas have a response rate of 15%. In 1971, the Southern Institute has begun research and suggested that combination therapy with doxorubicin and anti-melanomas, especially when the amount is sufficient