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目的观察茵栀黄口服液联合间隙蓝光照射佐以双歧杆菌三联活菌治疗新生儿黄疸的临床效果。方法选取医院收治的新生儿黄疸患儿360例,随机分为对照组和观察组,每组180例。对照组采用常规治疗,观察组则采用茵栀黄口服液联合间隙蓝光照射佐以双歧杆菌三联活菌治疗。比较2组患儿治疗前后经皮胆红素水平及治疗时间长短,比较治疗后2组治疗效果、不良反应发生率。结果治疗后,2组患儿经皮胆红素水平均明显下降,且观察组下降幅度优于对照组(P均<0.01);观察组黄疸消退时间短、总有效率高、不良反应率低,与对照组比较,差异均有统计学意义(P<0.05或P<0.01)。结论茵栀黄口服液联合间隙蓝光照射佐以双歧杆菌三联活菌治疗新生儿黄疸具有良好的治疗效果,可显著降低患儿经皮胆红素水平,治疗时间短,不良反应少,值得临床推广应用。
Objective To observe the clinical effect of Yinzhihuang oral liquid combined with interstitial blue light irradiation combined with Bifidobacterium triple viable bacteria in the treatment of neonatal jaundice. Methods 360 cases of neonatal jaundice admitted to hospital were randomly divided into control group and observation group with 180 cases in each group. The control group with conventional treatment, the observation group was Yinzhihuang oral solution combined with interstitial blue light irradiation combined with Bifidobacterium triple viable bacteria. The level of transcutaneous bilirubin and the duration of treatment before and after treatment were compared between two groups. The treatment effect and the incidence of adverse reactions were compared between the two groups. Results After treatment, the transdermal bilirubin levels in both groups were significantly decreased, and the decline rate in the observation group was better than that in the control group (all P <0.01). The jaundice subsided time was short, the total effective rate was high and the rate of adverse reactions was low , Compared with the control group, the difference was statistically significant (P <0.05 or P <0.01). Conclusion Yinzhihuang oral combined with interstitial blue light irradiation combined with Bifidobacterium triple viable bacteria treatment of neonatal jaundice has a good therapeutic effect, can significantly reduce children with transcutaneous bilirubin levels, the treatment time is short, fewer adverse reactions, it is worth clinical Promote the application.