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调节性T细胞(Treg)抑制免疫反应,诱导并维持免疫耐受。糖蛋白A为主的重复序列(GARP)是一种富含亮氨酸重复序列的跨膜蛋白,在免疫细胞中特异表达于活化的天然调节性T细胞(n Treg)表面。GARP与Treg表面的潜在转化生长因子β(L-TGF-β)结合,促进TGF-β的活化和分泌,与FOXP3形成正反馈环调节,增强Treg免疫抑制功能。GARP~+Treg在动脉粥样硬化、急性冠脉综合征、肠道炎症、肿瘤等多种疾病中发挥免疫调节功能,具有潜在临床应用价值。
Regulatory T cells (Tregs) suppress the immune response, induce and maintain immune tolerance. The glycoprotein A-based repeat (GARP) is a leucine-rich transmembrane protein that is specifically expressed in immune cells on the surface of activated native regulatory T cells (nTregs). GARP binds to the potential transforming growth factor β (L-TGF-β) on the surface of Treg, promotes the activation and secretion of TGF-β, regulates positive feedback loop with FOXP3 and enhances the immunosuppressive function of Treg. GARP ~ + Treg plays an immunomodulatory role in many diseases such as atherosclerosis, acute coronary syndrome, intestinal inflammation and tumor, and has potential clinical value.