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目的进一步探讨抗心磷脂抗体（ACA）在狼疮性肾炎临床和病理改变中的意义。方法采用ELISA方法对58例狼疮性肾炎患者血清进行了ACA检测，并对肾活检标本加做了Lendrum染色以显示肾小球微血栓。结果在狼疮性肾炎中，IgG型ACA和IgM型ACA的阳性率分别为39．7％和10．3％。IgG型ACA阳性患者具有流产发生率增高（P＜0．01），血小板减少发生率增高（P＜0．05），血清IgG水平增高（P＜0．01），C3水平降低（P＜0．05），以及抗核抗体谱中多种抗体阳性率增高特点。结论ACA阳性狼疮性肾炎患者，常具有流产，血小板减少发生率增高，以及较严重的免疫紊乱；ACA以Ⅱ型狼疮性肾炎常见，但未发现ACA与狼疮性肾炎病理活动有关。
Objective To further explore the significance of anticardiolipin antibodies (ACA) in the clinical and pathological changes of lupus nephritis. Methods Serum samples from 58 patients with lupus nephritis were detected by ELISA. Lendrum staining was performed on renal biopsy specimens to show glomerular microthrombus. Results In lupus nephritis, the positive rates of ACA of IgG type ACA and IgM were 39.7% and 10.3% respectively. The patients with ACA positive IgG had the higher incidence of miscarriage (P <0.01), thrombocytopenia (P <0.05), serum IgG (P <0.01) and C3 .05), as well as anti-nuclear antibody spectrum in a variety of antibodies positive rate increased characteristics. Conclusion ACA-positive patients with lupus nephritis often have abortion, increased incidence of thrombocytopenia, and more severe immune disorders; ACA to type l lupus nephritis common, but did not find ACA and pathological activities of lupus nephritis.