二萜生物碱是一类具有多桥环骨架和特殊取代模式的天然产物,是萜类生物碱中最大的一个家族.由于其复杂多样化的结构和显著的生理活性,二萜生物碱的化学合成工作受到了世界各地研究小组的广泛关注.近日,四川大学华西药学院秦勇教授、刘小宇副研究员及其合作者依据二萜生物碱的生源合成假说,成功地通过仿生的方式合成 Diterpene alkaloids are a kind of natural products with multi-bridged ring skeleton and special substitution patterns and are the largest family of terpenoid alkaloids. Due to its complex and diverse structure and significant physiological activity, diterpene alkaloids Recently, researchers at Qinhua University, Sichuan University, Associate Professor Liu Xiaoyu and their collaborators have succeeded in biomimetic synthesis based on the hypothesis of biogenic synthesis of diterpene alkaloids.