硫酸庆大霉素是常用的抗生素类药,其滴眼液在临床上用于结膜炎、角膜炎等。按中国药典95版及湖北省医院制剂规范均采用抗生素微生物测定法测定硫酸庆大霉素的含量,但作为一般初步质量控制尚感不便,不适合于医院快速制剂分析。笔者参考有关文献,并根据硫酸庆大霉素溶液的右旋特性设计了旋光法,经试验,结果较为满意。 Gentamicin sulfate is a commonly used antibiotic drugs, its eye drops for clinical use in conjunctivitis, keratitis and so on. According to the Chinese Pharmacopoeia 95 edition and the Hubei Provincial Hospital preparation specifications are determined by antibiotic microbial assay gentamicin sulfate content, but as a general preliminary quality control is still inconvenient, not suitable for rapid analysis of the hospital. I refer to the literature, and according to the right-handed characteristics of gentamicin sulfate solution designed optical rotation, the test, the results are more satisfactory.