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目的比较热毒宁注射液联合利巴韦林气雾剂与单纯静滴利巴韦林注射液用于儿童手足口病临床治疗效果。方法选择2014年5月~2014年8月在儿科门诊治疗手足口病患儿150例。随机分为观察组,对照组各75例,观察组予热毒宁注射液联合利巴韦林气雾剂治疗,对照组予利巴韦林注射液治疗,5天为一疗程,比较两组疗效。结果观察组临床治疗总有效率96%,对照组有效率79.7%;观察组疗效明显优于对照组(P<0.05),观察组患儿平均退热时间,口腔疱疹和溃疡愈合时间,手足疱疹消退时间均短于对照组(P<0.01),两组患儿在治疗期间均未发生严重的毒副反应。结论热毒宁注射液联合利巴韦林气雾剂治疗儿童手足口病安全且临床效果显著。
Objective To compare the clinical efficacy of Renduining injection combined with ribavirin aerosol and simple intravenous infusion of ribavirin in the treatment of hand, foot and mouth disease in children. Methods From May 2014 to August 2014, 150 children with HFMD were treated in pediatric outpatient department. Randomly divided into observation group and control group, 75 cases in each group. The observation group was treated with Renduining injection combined with ribavirin aerosol. The control group was treated with ribavirin injection. Five days was a course of treatment. The two groups were compared Efficacy. Results The total effective rate was 96% in the observation group and 79.7% in the control group. The curative effect in the observation group was significantly better than that in the control group (P <0.05). The mean antipyretic time, oral herpes and ulcer healing time, The subsided time was shorter than that of the control group (P <0.01). No serious adverse reactions occurred in both groups during the treatment. Conclusion Reveduning injection combined with ribavirin aerosol in the treatment of children with hand-foot-mouth disease is safe and the clinical effect is remarkable.