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目的比较苯磺酸左旋氨氯地平片与苯磺酸氨氯地平对原发性高血压患者血压变异性(BPV)的影响。方法选择首次诊断、且未经降压药物治疗的1级原发性高血压患者100例,随机分为对照组和研究组,每组各50例患者。对照组患者口服苯磺酸氨氯地平(商品名:络活喜)5 mg/d,研究组患者口服苯磺酸左旋氨氯地平(商品名:施慧达)2.5 mg/d。2组共治疗4周。治疗前后根据24 h动态血压监测(ABPM)分析血压变异性(BPV)。结果对照组、研究组血压达标率比较无统计学差异(87.8%vs 83.3%,χ~2=0.384,P=0.536)。2组患者治疗前、治疗后24 h SBPV、24 h DBPV、日间SBPV、日间DBPV、夜间SBPV、夜间DBPV之间互相比较均无统计学差异(P均>0.05),对照组及研究组药物治疗后24 h SBPV、24 h DBPV、日间SBPV、日间DBPV、夜间SBPV、夜间DBPV均较治疗前显著降低(P均<0.001),但2组之间比较均无显著性差异(P均>0.05)。结论对于首次诊断、且未治疗的1级高血压病患者,苯磺酸左旋氨氯地平2.5 mg/d与苯磺酸氨氯地平5 mg/d降低BPV的作用相似。
Objective To compare the effects of levamlodipine besylate and amlodipine besylate on blood pressure variability (BPV) in patients with essential hypertension. Methods One hundred patients with grade 1 essential hypertension who were diagnosed for the first time without treatment with antihypertensive drugs were randomly divided into control group and study group with 50 patients in each group. Patients in the control group were treated with amlodipine besylate (trade name: Lovastatin) 5 mg / d. Patients in the study group were given oral levamlodipine besylate (trade name: Shi Huida) 2.5 mg / d. Two groups were treated for 4 weeks. Blood pressure variability (BPV) was analyzed by 24-h ambulatory blood pressure monitoring (ABPM) before and after treatment. Results There was no significant difference between the two groups (87.8% vs 83.3%, χ ~ 2 = 0.384, P = 0.536). There were no significant differences in SBPV, 24 h DBPV, SBPV in daytime, DBPV in daytime, SBPV in nighttime and DBPV in nighttime between two groups before treatment, 24 h after treatment (P all> 0.05) The SBPV, 24 h DBPV, daytime SBPV, daytime DBPV, nocturnal SBPV and nocturnal DBPV at 24 h after treatment were significantly lower than those before treatment (all P <0.001), but there was no significant difference between the two groups (P All> 0.05). Conclusions Levamlodipine besylate 2.5 mg / d is similar to BPV in patients with first-grade, untreated grade 1 hypertension, and amlodipine besylate 5 mg / d.