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目的:茵陈蒿汤加味方配合西医方法治疗辨证为肝胆湿热型的慢性乙型肝炎的疗效及对其免疫调节功能的影响。方法:将70例辨证为肝胆湿热型慢性乙型肝炎患者随机分为治疗组和对照组各35例。对照组给予西药抗病毒(给予阿德福韦酯)及护肝治疗,治疗组在此基础上,给予茵陈蒿汤加味方治疗,2个月后评价疗效。结果:治疗后临床症状改善及降低TBIL、ALT、AST、血清HBV-DNA滴度下降方面治疗组均优于对照组,具有统计学意义(P<0.05);治疗后治疗组CD3、CD4水平的升高,CD4/CD8水平恢复正常值率方面治疗组均优于对照组,具有统计学意义(P<0.05)。结论:中西医结合治疗辨证为肝胆湿热型的慢性乙型肝炎可显著提高疗效及增强免疫功能的作用。
OBJECTIVE: To investigate the curative effect of Yinchenhao decoction combined with western medicine on syndrome differentiation of hepatitis B and damp-heat type of chronic hepatitis B and its effect on immune regulation. Methods: Seventy patients with syndrome of hepatobiliary and cholestatic hepatitis B were randomly divided into treatment group (35 cases) and control group (35 cases). The control group was given Western antiviral (given adefovir dipivoxil) and liver protection treatment. On the basis of this, the treatment group was treated with Yinchenhao Decoction, and after 2 months, the curative effect was evaluated. Results: After treatment, the improvement of clinical symptoms and the decrease of TBIL, ALT, AST, serum HBV-DNA titer in the treatment group were better than those in the control group (P <0.05); after treatment, the levels of CD3 and CD4 The levels of CD4 / CD8 in the treatment group were better than those in the control group, with statistical significance (P <0.05). Conclusion: The combination of traditional Chinese and Western medicine treatment of chronic hepatitis B with hepatobiliary-damp-heat syndrome can significantly improve the efficacy and enhance immune function.