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目的观察小剂量氯丙嗪持续静脉滴注治疗早期高热性重度脑出血的疗效与安全性。方法选择发病后 72小时内体温 39℃以上重度脑出血患者共 6 7例 ,随机分为两组 ,观察组在锥颅血肿抽吸引流的基础上 ,加用氯丙嗪 2 5mg加 5%葡萄糖溶液 2 50～ 50 0ml持续静脉滴注 ,并配合物理降温 ;对照组只采用一般解热药物配合物理降温治疗。结果观察组病死率显著低于对照组 (P <0 .0 5) ;患者日常生活能力两组比较 ,观察组明显优于对照组 (P <0 .0 5)。结论小剂量氯丙嗪持续静滴治疗早期高热性重度脑出血 ,无明显副作用 ,使用安全 ,疗效较好
Objective To observe the efficacy and safety of continuous intravenous infusion of low-dose chlorpromazine in the treatment of early-onset, severe, and severe intracerebral hemorrhage. Methods Sixty-seven patients with severe cerebral hemorrhage above 39 ℃ within 72 hours after onset were randomly divided into two groups. On the basis of aspiration and drainage of cone cranial hematoma, the observation group was treated with 25 mg chlorpromazine plus 5% glucose Solution 50 ~ 50 0ml continuous intravenous infusion, and with the physical cooling; control group only with general antipyretic drugs with physical cooling treatment. Results The case fatality rate in the observation group was significantly lower than that in the control group (P <0.05). The daily living ability of the patients in the observation group was significantly better than that in the control group (P <0.05). Conclusion Small dose of chlorpromazine sustained intravenous infusion of high fever in patients with severe intracerebral hemorrhage, no obvious side effects, safe, effective