晚发型脊柱骨骺发育不良伴进行性关节病颇少见 ,国内报道亦较少 ,现将我科遇到的 2例报告如下。1　病例介绍1.1　例 1　男 ,9岁 ,腰痛 ,四肢关节肿胀 ,疼痛 3年。曾在外院拍片诊为“大骨节病”,服药 (药名不详 )后无明显效果 ,遂来我院就诊。查体 :五官对称 ,身材矮小 ,躯干短 Late onset spina epiphyseal dysplasia with progressive joint disease is quite rare, less domestic reports, now we encounter 2 cases reported as follows. 1 case description 1.1 cases 1 male, 9 years old, low back pain, swollen joints, pain for 3 years. Once in the outpatient filming clinic as “Kashin-Beck disease”, medication (unknown drug name) no significant effect, then came to our hospital. Physical examination: facial features symmetry, short stature, short trunk