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采用正交试验，以漫膏得率和大黄酸含量为考察指标，对大黄药材的煎煮条件进行优选，结果表明以8倍于生药重量的水浸泡30分钟，煎煮10分钟为佳；同时进行了方法学研究，结果表明方法可行、工艺稳定、重现性好。
Orthogonal experiments were conducted to optimize the decoction conditions of rhubarb by using the diffuser yield and rhein content as indicators. The results showed that it was better to soak in water at 8 times the weight of crude drug for 30 minutes and decoction for 10 minutes. A methodological study was conducted and the results showed that the method is feasible, the process is stable, and the reproducibility is good.