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为了观察甲基特丁基醚（ＭＴＢＥ）在活体内溶解胆石的安全剂量及其毒、副作用，选用体重８．５～１６．４ｋｇ的杂种犬１０只，将直径约１ｃｍ的人胆囊结石Ⅰ、Ⅳ型各１块置入犬胆囊中，同时于胆囊内置入硅胶管１根，引出腹外，间断分次注入ＭＴＢＥ，随机确定灌注剂量，同时监测呼吸等生命体征变化，手术前后分别行肝、肾功能检查及肝、胆囊组织病理切片检查。结果：①动物模型的Ⅰ、Ⅳ型结石均全部迅速溶解，但ＭＴＢＥ有一定毒性，其对中枢神经系统有一定的抑制作用，应用时须严格掌握单位时间内的灌注剂量及总量（控制在６０ｍｌ左右）；②实验犬实验前后的肝、肾功能检查无异常；③病理检查结果提示ＭＴＢＥ对胆囊组织无明显损伤，无严重炎性反应，给药后短期内肝窦和中央静脉有凝血现象，但其组织学变化是可逆的。
In order to observe the safe dose of MTBE dissolved in vivo and its toxic and side effects, 10 dogs with body weight 8.5 ~ 16.4kg were selected, and the gallbladder stones with a diameter of 1cm, Ⅳ type 1 into the canine gallbladder, at the same time in the gallbladder into a silicone tube, leads to the abdomen, intermittent injection of MTBE, a random determination of perfusion dose, while monitoring changes in vital signs such as respiration, before and after surgery, respectively, liver, Renal function tests and liver, gallbladder tissue biopsy. Results: ①The type Ⅰ and type Ⅳ stones of animal model all dissolved rapidly, but MTBE was toxic. It had a certain inhibitory effect on the central nervous system. When applied, the dosage and total amount of perfusion per unit time should be strictly controlled 60ml or so); ②The liver and kidney function tests before and after experimental dogs were normal; ③The results of pathological examination showed that MTBE had no obvious injury to gallbladder tissues, no serious inflammatory reaction, coagulation phenomenon of sinusoids and central venous shortly after administration , But its histological changes are reversible.