本文用D—氨基半乳糖诱发大白鼠急性肝功能衰竭伴发脑病,然后测定脑中5—羟色胺(5—HT)、5—羟吲哚乙酸(5—HIAA)和血清、脑中芳香族氨基酸(AAA)、总氨基酸含量的变化,并与健康组对照。结果,Ⅰ级昏迷鼠仅有脑、血清总氨基酸高于健康组,Ⅱ、Ⅲ、Ⅳ级昏迷鼠除Ⅱ级脑5—HT和血清色氨酸与健康组无差别外,其余各项均显著高于健康组。Ⅱ、Ⅲ、Ⅳ级昏迷鼠血清AAA及脑中AAA、5—HT、5—HIAA均升高,且随昏迷程度加深而增加,说明肝昏迷与血中AAA变化有关。 In this paper, D-galactosamine-induced acute liver failure associated with encephalopathy in rats, and then measured 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and serum brain aromatics amino acids (AAA), total amino acid content changes, and with the control group. As a result, the first-grade fainted rats had only brain, and the total serum amino acids were higher than those in the healthy group. The levels of Ⅱ-Ⅲ and Ⅳ-fainted rats were not significantly different from those of grade Ⅱ brain 5-HT and serum tryptophan, Above health group. Serum AAA and AAA, 5-HT and 5-HIAA in Ⅱ, Ⅲ and Ⅳ -failed rats were both increased and increased with the degree of coma, suggesting that hepatic coma is associated with changes in blood AAA.