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目的:对上海市奉贤区妇女进行子宫颈人乳头瘤病毒(HPV)亚型感染的筛查,以探讨其分布规律。方法:采用HybriM ax技术,对2009年1~12月上海市奉贤地区20~67岁有性生活的妇女进行子宫颈HPV基因分型检测。结果:从5 729例中筛选出HPV亚型阳性患者952例(HPV亚型阳性率16.62%),其中HPV亚型单一感染689例,多重感染263例(包括双重感染182例,三重感染54例,四重感染18例,五重感染2例,六重感染4例,七重感染2例,八重感染1例)。居前6位的是:HPV 16亚型(27.00%)、52亚型(23.32%)、58亚型(10.19%)、53亚型(9.77%),6亚型(7.46%)、18亚型(6.93%)。未检测到44亚型。结论:HPV亚型检测用于子宫颈病变的筛查,不仅可确定具体HPV型别,还可判断多重感染,以高危型HPV 16型感染最多,HPV感染亚型分布有一定的区域性,有利于预测病变的转归。
Objective: To screen the HPV subtype infection of women in Fengxian District of Shanghai to explore its distribution. Methods: HybriM ax technique was used to detect HPV genotypes in women aged 20-67 years in Fengxian, Shanghai from January to December in 2009. Results: A total of 952 HPV subtypes (16.62%) were screened out of 5 729 cases. Among them, 689 were HPV subtypes with single infection and 263 multiple infections (including 182 cases of double infection and 54 cases of triple infection , Tetrad infection in 18 cases, five cases of infection in two cases, six cases of infection in four cases, seven cases of infection in two cases, eight cases of infection in 1 case). The top 6 were HPV 16 subtypes (27.00%), 52 subtypes (23.32%), 58 subtypes (10.19%), 53 subtypes (9.77%), 6 subtypes (7.46%), 18 subtypes Type (6.93%). No 44 subtypes were detected. Conclusion: The HPV subtype test can be used for the screening of cervical lesions. Not only the specific HPV type but also the multiple infections can be determined. HPV type 16 infection is the most common and HPV subtype is localized. There are Conducive to predict the outcome of the disease.