掌跖牙周综合征(Papillon-Lefevre Syndrome)是一种罕见的疾病,尤其见于同胞三姊妹更属罕见,现报告如下: 患者段×,女,19岁,要求修复缺失牙于1982年4月8日初诊,患者足月顺产,3个月时开始掌跖皮肤角化,反复脱落,逐渐加重,且有皲裂,手脚心无汗,喜浸泡水中。8～9月萌出乳牙,3岁时乳牙全部萌出,但不久开始溢脓,松动,相继脱落,6～7岁时开始萌出恒牙,13～14岁恒牙基本萌出,1年后又开始牙周 Papillon-Lefevre Syndrome is a rare disease, especially seen in siblings sisters more rare, are reported as follows: patients ×, 19-year-old female, requiring deletion of missing teeth in April 1982 Early diagnosis on the 8th, patients with full-term follow-up, palmoplantar skin keratosis at 3 months, repeatedly shedding, and gradually increased, and there chapped, hands and feet without sweat, hi soaked in water. 8 ~ September eruption of deciduous teeth, 3-year-old deciduous teeth all eruptions, but soon began to overflow pus, loose, one after another off, 6 to 7 years old began to erupt permanent teeth, 13 to 14-year-old permanent teeth basic eruption, week