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运用自旋捕捉电子自旋共振技术直接捕捉到兔肝、肾微粒体脂质过氧化形成的脂自由基L~(?),体外亚细胞水平的实验研究表明各种顺铂类配合物促进L~(?)形成的作用和MDA的增长,血浆抗坏血酸(VC)库水平及血液GSH-Px活性的降低呈相似的变化趋势。作用的强弱与配合物的化学结构有关。顺铂的肝毒性与肾毒性一样,可能与自由基介导的氧化性损伤有关。
The spin-capture electron spin resonance technique was used to directly capture the lipid peroxidation of rabbit liver and kidney microsomal lipid L ~ (?), In vitro subcellular levels of experimental studies have shown that various cisplatin complexes promote L ~ (?) Formed a similar trend with the increase of MDA, the level of plasma ascorbic acid (VC) and the decrease of blood GSH-Px activity. The strength and role of the complex chemical structure. The hepatotoxicity of cisplatin, like nephrotoxicity, may be related to free radical-mediated oxidative damage.