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目的探讨冠心病合并妇科恶性肿瘤患者胃饥饿素(Ghrelin)/肥胖抑制素(obestatin)比值变化及临床意义。方法收集女性冠心病和妇科恶性肿瘤患者211例作为研究对象,根据检查结果分为冠心病肿瘤组(n=42)、单纯肿瘤组(n=55)、单纯冠心病组(n=64)及对照组(n=50)。采用ELISA法测定血清胃饥饿素、肥胖抑制素水平。根据冠状动脉造影结果采用Gensini积分评估冠状动脉病变程度。结果冠心病肿瘤组、单纯肿瘤组和单纯冠心病组患者的Ghrelin/obestatin比值显著低于对照组,差异均有统计学意义(P<0.05)。冠心病肿瘤组患者的Ghrelin/obestatin比值与Gensini积分呈负相关(r=-0.55,P<0.05)。结论冠心病合并妇科恶性肿瘤患者的Ghrelin/obestatin比值与冠状动脉病变程度密切相关。Ghrelin/obestatin比值在预测冠心病合并妇科恶性肿瘤中有一定的辅助参考价值。
Objective To investigate the changes of Ghrelin / obestatin in patients with coronary heart disease complicated with gynecologic malignancies and its clinical significance. Methods A total of 211 women with coronary heart disease and gynecologic malignancy were enrolled in this study. According to the results of the study, they were divided into coronary heart disease group (n = 42), simple tumor group (n = 55), simple coronary heart disease group (n = 64) Control group (n = 50). Serum ghrelin and obesity inhibin levels were measured by ELISA. Coronary angiography was assessed by Gensini score based on coronary angiography. Results The Ghrelin / obestatin ratio in patients with coronary heart disease, simple tumor and simple coronary heart disease was significantly lower than that of the control group (P <0.05). The Ghrelin / obestatin ratio in patients with coronary heart disease was negatively correlated with the Gensini score (r = -0.55, P <0.05). Conclusion The Ghrelin / obestatin ratio in patients with coronary heart disease and gynecologic malignancies is closely related to the degree of coronary artery lesion. Ghrelin / obestatin ratio in the prediction of coronary heart disease with gynecological malignancies have some auxiliary reference value.