环酰胺已广泛应用于临床,其疗效并不亚于N′-4-甲基苯磺酰-N~2-H-丁基異尿素,且毒性较小,但作用机制的研究尚少。作者企图探讨该药物:1)对正常动物降血糖的持续时间和作用强度;2)对无胰腺或无β细胞的胰岛是否有作用;3)对胰岛素的作用是否增强。作者将正常免,正常及糖尿病狗,分别注射各种药物,间隔不同时间取血,测定血糖含 Cyclic amides have been widely used clinically, and their efficacy is as good as that of N’-4-methylbenzenesulfonyl-N ~ 2-H-isobutyl-urea with less toxicity. The authors sought to investigate the drug’s effects on 1) the duration and intensity of hypoglycaemic effects on normal animals, 2) the effect on pancreatic islets without or with beta cells, and 3) the effect on insulin. The author will be normal, normal and diabetic dogs, were injected with various drugs, blood at different intervals to determine blood sugar