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目的研究细胞因子与自身免疫性甲状腺病(AITD)中的关系。方法对71例Graves病(GD)、35例桥本甲状腺炎(HT)患者及36例对照者检测了血清中肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6和甲状腺激素及相关抗体水平。结果各组TNF-α、IL-6显著高于对照组。GD组TNF-α/IL-6比值显著低于对照组,HT组TNF-α/IL-6比值显著高于对照组。结论Th1、Th2细胞因子共同参与AITD的发生发展过程。Th2介导的体液免疫在GD的病理反应中起主导作用;Th1介导的细胞免疫在HT的病理反应中起主导作用。
Objective To study the relationship between cytokines and autoimmune thyroid disease (AITD). Methods Tumor necrosis factor (TNF) -α, interleukin (IL) -6 and thyroid hormones were detected in 71 patients with Graves disease (GD), 35 patients with Hashimoto’s thyroiditis (HT) and 36 controls. Related antibody levels. Results The levels of TNF-α and IL-6 in each group were significantly higher than those in the control group. The ratio of TNF-α / IL-6 in GD group was significantly lower than that in control group. The ratio of TNF-α / IL-6 in HT group was significantly higher than that in control group. Conclusions Th1 and Th2 cytokines participate in the development of AITD. Th2-mediated humoral immunity plays a leading role in the pathological response of GD; Th1-mediated cellular immunity plays a dominant role in the pathological response of HT.