１９９５年１月～１９９６年５月用雌激素替代治疗，采用随机分组、双盲对照方法观察４０例绝经期心血管病。治疗组２２例应用国产尼尔雌醇片，初始剂量５ｍｇ每月１次，第２个月为２５ｍｇ每月２次，疗程为１年；对照组应用安慰剂。治疗组减少心绞痛发作、改善心肌缺血、室性早搏的总有效率均明显高于对照组（分别为８３３％、８５７％、８７５％）（Ｐ＜００１）。应用尼尔雌醇片后降低ＴＣ、ＬＤＬ、升高ＨＤＬ。结果表明，尼尔雌醇片能降低绝经期心血管疾病的发生率。 January 1995 ~ May 1996 estrogen replacement therapy, randomized, double-blind control 40 cases of menopausal cardiovascular disease observed. The treatment group, 22 cases of domestic nilestia alcohol tablets, the initial dose of 5mg once a month, the second month of 2  5mg twice a month, the course of treatment for 1 year; placebo in the control group. In the treatment group, the total effective rate of reducing angina pectoris, improving myocardial ischemia and ventricular premature beats were significantly higher than that of the control group (833%, 857%, 875%, respectively) (P <001). Application of nilestriol tablets reduce TC, LDL, increase HDL. The results show that nilestriol tablets can reduce the incidence of cardiovascular disease in menopausal.