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本文报道19例免疫性血小板减少性紫癜(ITP)脾脏小剂量照射的效果。选择对皮质类固醇治疗无效或需要较大剂量药物维持,以及合并症较多行脾切除危险性较高的老年患者。11例为慢性ITP,8例继发性ITP,男9例,女10例,年龄57～92岁,平均77岁。采取脾区外照射,短程小剂量,疗程1～6周,放疗总量75～1370cGy。结果,11例慢性ITP中,8例有效,血小板平均值由17×10~9/L升高到129×10~9/L,配对t检验显示基础值与平均值有显著性差异(P=0.002)。其中
This article reports 19 cases of immune thrombocytopenic purpura (ITP) spleen small dose irradiation. Choose for corticosteroid therapy ineffective or require larger doses of drug maintenance, and more complications of splenectomy in elderly patients at higher risk. 11 cases of chronic ITP, 8 cases of secondary ITP, 9 males and 10 females, aged 57 to 92 years, mean 77 years. Radiotherapy outside the spleen to take short-range low-dose course of treatment of 1 to 6 weeks, the total amount of radiotherapy 75 ~ 1370cGy. Results: Of the 11 patients with chronic ITP, 8 were effective and the average platelet count was increased from 17 × 10 ~ 9 / L to 129 × 10 ~ 9 / L. The paired t-test showed that the basal value was significantly different from the mean (P = 0.002). among them