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目的:通过检测HBxAg在HBsAg阳性的原发性肝癌中的表达及意义的研究,以进一步了解HBV X基因在原发性肝癌发展与转归中的作用。方法:对60例肝癌病人HBxAg在原发性肝癌组织中的表达进行免疫组化检查,并将检测结果进行统计分析。结果:HBxAg在肝癌单发灶组(Ⅰ组)病人中表达为阴性、阳性者分别为8、20例;在肝癌伴肝内转移灶组(Ⅱ组)病人中表达为阴性、阳性者分别为6、26例;肝癌病人外周血中的HBV DNA在Ⅰ组和Ⅱ组阳性数分别为5、7例,HBeAg在I组和Ⅱ组阳性数分别为7、10例。结论:乙肝X基因不仅与肝癌的发生有一定的关系,而且与肝癌转移也有一定的关系。
Objective: To study the expression and significance of HBxAg in HBsAg-positive primary hepatocellular carcinoma (HCC) to further understand the role of HBV X gene in the development and prognosis of primary HCC. Methods: The expression of HBxAg in primary hepatocellular carcinoma was examined by immunohistochemistry in 60 patients with hepatocellular carcinoma, and the results were statistically analyzed. RESULTS: HBxAg was negative and positive in patients with liver cancer single-site group I (group I) was 8, 20 cases; in liver cancer with intrahepatic metastasis group (II group) patients were negative, positive were Sixty-six patients were included in this study. The positive numbers of HBV DNA in peripheral blood of patients with hepatocellular carcinoma in group I and II were 5 and 7, respectively. The positive numbers of HBeAg in group I and II were 7 and 10, respectively. Conclusion: The hepatitis B X gene not only has a certain relationship with the occurrence of liver cancer, but also has a certain relationship with the liver cancer metastasis.