本文证实给小鼠黄芪皂苷甲后出现镇痛作用,其镇痛作用较度冷丁弱而短。根据对小鼠腹腔注射醋酸产生扭体反应抑制率测得静脉注射黄芪皂苷甲的ED50为47.8±3.4mg/kg;由热板法测得的ED50为25.4±1.5mg/kg。黄芪皂苷甲也能明显延长硫喷妥钠所致小鼠的麻醉时间。此外,黄芪皂苷甲还能使豚鼠离体回肠张力下降。 This article confirms that analgesic effects occur after administration of astragaloside A to mice, and its analgesic effect is weaker and shorter than that of pethidine. The ED50 of intravenous injection of baicalin saponin A was 47.8±3.4 mg/kg, and the ED50 measured by the hot plate method was 25.4±1.5 mg/kg. Astragaloside A can also significantly prolong the anesthesia time of thiopental-induced mice. In addition, astragaloside A can also reduce the guinea pig isolated ileum tension.