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腹腔化疗是卵巢癌化疗的重要组成部分,近年报道较多,对其优越性和局限性有了进一步了解,筛选出一些有效药物,疗效是肯定的。本文就有关问题进行讨论。1 优点和局限性1.1 优点卵巢癌是一种全腹性疾病,即使是临床早期也会发生亚临床转移。腹腔给药使药物与肿瘤直接接触,而且浓度高。与体循环测量结果相比,某些细胞毒药物在腹腔的浓度高于血浆浓度10～1000倍。对卵巢癌有效的化疗药物的抗肿瘤活性与浓度相关,腹
Intraperitoneal chemotherapy is an important part of chemotherapy for ovarian cancer, reported in recent years more, its advantages and limitations have been further understanding, screening out some effective drugs, the curative effect is affirmed. This article discusses the issues. 1 Advantages and limitations 1.1 Advantages Ovarian cancer is a total abdominal disease, even in early clinical subclinical metastasis will occur. Intraperitoneal drug administration and tumor direct contact, but high concentrations. Compared with the results of the systemic circulation, some cytotoxic drugs in the peritoneal concentration higher than the plasma concentration of 10 to 1000 times. The anti-tumor activity of chemotherapeutic drugs that are effective on ovarian cancer is related to concentration, the abdomen