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目的:通过分析1例卵巢癌伴脑转移患者疼痛的治疗方案,为临床药师参与该类型的疼痛治疗提供借鉴和参考。方法:对患者进行全面和动态评估,查阅相关文献和指南,协助医师调整镇痛方案。结果:在综合考虑患者的临床疾病、疼痛特征及程度、心理状况等多方面因素后,镇痛方案最终调整为以强阿片类药物为基础,联合使用三环类抗抑郁药和抗惊厥药物,同时加用激素类药物,使得该患者得到有效的镇痛治疗,同时避免不良反应的发生。结论:卵巢癌伴脑转移引起的疼痛往往比较严重且难治,临床药师需对患者进行全面和动态的评估,规范阿片类药物滴定过程,同时结合患者的疼痛情况合理使用辅助药物,最终达到尽快控制疼痛,提高患者生存质量的目标。
OBJECTIVE: To provide a reference for clinical pharmacists to participate in this type of pain treatment by analyzing the treatment of 1 patient with ovarian cancer and brain metastases. Methods: A comprehensive and dynamic assessment of patients, access to relevant literature and guidelines to help physicians adjust the analgesic program. Results: After comprehensive consideration of various factors such as patient’s clinical condition, pain characteristics and degree, psychological condition and other factors, the analgesic program was finally adjusted to be based on strong opioid drugs, tricyclic antidepressants and anticonvulsants, At the same time add hormonal drugs, making the patient effective analgesic treatment, while avoiding the occurrence of adverse reactions. Conclusion: The pain caused by ovarian cancer with brain metastasis is often severe and refractory. The clinical pharmacist needs to make a comprehensive and dynamic assessment of the patient, standardize the opiate titration process, and at the same time make rational use of auxiliary drugs according to the patient’s pain condition, and finally achieve as soon as possible Control pain, improve patient quality of life goals.