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目的探讨酚妥拉明联合多巴胺治疗典型左心衰竭老年患者的疗效。方法选择2010年2月～2011年12月某院心内科收治的典型左心衰竭老年患者90例,按随机数字表法分为观察组和对照组各45例。对照组给予左心衰常规治疗,观察组在此基础上给予酚妥拉明和多巴胺。结果观察组总有效率为86.7%(39/45),对照组为68.9%(31/45),差异有统计学意义(P﹤0.05);观察组用药后SV、CO、LVEF显著优于对照组(P﹤0.05),用药2h时HR、MAP和SpO2均显著优于对照组(P﹤0.05);观察组头痛2例,滴速减慢后缓解,未发现其他不良反应。结论酚妥拉明联合多巴胺治疗老年典型左心衰竭,能快速控制心衰,改善血流动力学和心功能,显著提高疗效,安全系数大,尤其适用于老年患者。
Objective To investigate the efficacy of phentolamine combined with dopamine in the treatment of elderly patients with typical left ventricular failure. Methods 90 elderly patients with typical left ventricular failure admitted to Department of Cardiology from February 2010 to December 2011 were randomly divided into observation group (45 cases) and control group (45 cases). The control group was given conventional treatment of left heart failure, and the observation group was given phentolamine and dopamine on this basis. Results The total effective rate was 86.7% (39/45) in the observation group and 68.9% (31/45) in the control group, the difference was statistically significant (P <0.05); SV, CO and LVEF in the observation group were significantly better than those in the control group (P <0.05). The HR, MAP and SpO2 were significantly better than those of the control group at 2h (P <0.05). The headache was observed in 2 cases in the observation group. The drip rate slowed down and relieved. No other adverse reactions were found. Conclusion Phentolamine combined with dopamine treatment of elderly patients with typical left heart failure, can quickly control heart failure, improve hemodynamics and heart function, significantly improve the efficacy, safety factor, especially for elderly patients.