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目的探讨奥扎格雷钠治疗急性脑梗死的临床疗效。方法急性脑梗死患者72例,随机分成治疗组和对照组,两组患者均给予控制血压、调脂、改善脑水肿、改善脑血循环及脑细胞代谢活化剂治疗,治疗组用5%葡萄糖注射液250 ml+奥扎格雷钠80 mg,静脉滴注,1日2次,疗程21 d;对照组用5%葡萄糖注射液250 ml+维脑路通注射液600 mg,静脉滴注,每日1次,疗程21 d。两组中有糖尿病者改用生理盐水稀释。治疗前后两组病例分别进行神经功能缺损程度评分。结果治疗组有效率86.1%,优于对照组58.3%(P<0.01),未发现明显不良反应。结论奥扎格雷钠治疗急性脑梗死安全有效。
Objective To investigate the clinical efficacy of ozagrel sodium in the treatment of acute cerebral infarction. Methods 72 patients with acute cerebral infarction were randomly divided into treatment group and control group. Both groups were given control blood pressure, lipid regulation, cerebral edema, cerebral blood circulation and metabolic activator of brain cells. The treatment group was treated with 5% glucose injection 250 ml + ozagrel sodium 80 mg twice daily for 21 days. The control group was treated with 250 ml 5% dextrose injection and 600 mg intravenous injection of Venoruton, once daily, Course of treatment 21 d. Diabetes in both groups with saline diluted. Before and after treatment, the two groups of patients were respectively scored for neurological deficit. Results The effective rate of the treatment group was 86.1%, which was better than that of the control group (58.3%, P <0.01). No obvious adverse reactions were found. Conclusion Ozagrel sodium is safe and effective in the treatment of acute cerebral infarction.