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脑卒中是老年人口中最常见的疾病之一.CD40受体在抗原呈递和T细胞二次激活中发挥重要作用.本研究评估了中国汉族人群中CD40-1C/T基因多态性与脑卒中及其两种亚型的关联性.研究样本996例,其中包括498例健康对照样本和498例病人样本(338例缺血性脑卒中样本和160例出血性脑卒中样本).对所有样本进行了CD40-1C/T多态性位点分型并统计分析,同时将本研究得出的缺血性脑卒中分析结果跟以往的研究进行荟萃分析.研究发现CD40-1C/T基因多态性与脑卒中、缺血性脑卒中及出血性脑卒中均显著关联,同时荟萃分析也表明缺血性脑卒中与CD40-1C/T基因多态性的关联与以往研究结果一致.本研究的发现表明CD40-1C/T基因多态性是脑卒中及其两种亚型的遗传风险因素.“,”Stroke is one of the most common diseases in the older population.CD40 receptor plays a key role 1n antigen presentation and T-cell secondary activation.This study evaluated the association between CD40-1C＞ T single nucleotide polymorphism and total stroke,ischemic stroke and hemorrhagic stroke in Han Chinese Population.A total of 996 subjects were recruited,including 498 healthy controls and 498 patients (338 ischemic stroke and 160 hemorrhagic stroke).CD40-1C＞T single nucleotide polymorphism was genotyped for statistical analysis.Meta-analysis of ischemic stroke was used to contextualize our studies with three previous studies.CD40-1C＞T single nucleotide polymorphism was significantly associated with total stroke (Padjusted =0.001,OR =1.41 [95％ CI =1.15-1.74]),ischemic stroke (Psdjusted =0.022,OR =1.33 [95％ CI =1.04-1.69]) and hemorrhagic stroke (Padjusted =0.017,OR =1.40 [95％ CI =1.06-1.86]).In meta-analysis,there was a significant association between CD40-1 C＞ T SNP and ischemic stroke (P ＜0.00001,OR =1.39 [95 ％ CI =1.25-1.56]) yielding 1.39 per T allele copy.The results of our study are consistent with previous reports.Our findings indicate that CD40-1C＞T polymorphisms may be a risk factor of stroke and its two subtypes.