对于吸入新生隐球菌后由肺发生播散性感染的问题早已为人们重视和研究,但对于鼻腔尤其是嗅粘膜部分所起的作用却知之甚少。 20只豚鼠分为2组,Ⅰ组不破坏嗅粘膜,Ⅱ组用2％硫化锌在滴入菌前3天选择性破坏鼻腔嗅粘膜部分。滴入的菌量为10~3(0.5ml,生理盐水悬液),之前先用二乙基乙醚抑制喷嚏反射。按规定的时间解剖动物,去皮肤的头部经福尔马林固定,于眶水平打开鼻腔后作梨鼻骨复 For the inhalation of Cryptococcus neoformans disseminated infection by the lung has long been people’s attention and research, but for the nasal cavity, especially the role of the olfactory mucosa is poorly understood. Twenty guinea pigs were divided into two groups. Group Ⅰ did not destroy the olfactory mucosa. Group Ⅱ selectively destroyed the nasal olfactory mucosa with 2% zinc sulfide 3 days before dropping into the bacteria. Drop in the amount of bacteria 10 to 3 (0.5ml, saline suspension), before using diethyl ether to inhibit sneeze reflex. According to the prescribed time dissecting animals, to the skin of the head fixed by formalin, after nasal opening at orbital level for nasal complex nasal complex