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由于海南省恶性疟原虫对氯喹普遍产生了抗性,所以于1979年开始,在全岛范围内停止使用氯喹防治恶性疟。为了了解停止使用氯喹后恶性疟原虫对氯喹抗性的消长情况,作者以该省乐东县为观察点,于1981—1991年间,每隔2—3年测定1次恶性疟原虫对氯喹的敏感性。结果发现,停止使用氯喹后,恶性疟原虫对氯喹的抗性呈逐渐降低趋势,体外法测得的抗性率由1981年的97.9％,降至1991年为60.9％(P<0.001),完全抑制裂殖体形成的平均剂量由1981年的10.46pmol/μl,降至1991年的3.02pmol/μl(P<0.001),需用大剂量(6.4pmol/μl)才能完全抑制裂殖体形成的病例比例,由1981年的83.3％,降为1991年的17.4％(P<0.001),而小剂量(1.6pmol/μl)即可抑制的病例比例,却由1981年的4.2％增加到1991年的60.8％(P<0.001)。体内法测得的抗性率,由1981年的84.2％,降为1991年的40％(P<0.001),RⅡ和RⅢ占抗性病例比例,由1981年的59.4％,降至1991年的37.5％(0.02>P>0.01)。
Because of the general resistance of Plasmodium falciparum to chloroquine in Hainan Province, beginning in 1979, the use of chloroquine was stopped and controlled throughout the island. In order to know the decline of chloroquine resistance of Plasmodium falciparum after stopping the use of chloroquine, the author used Ledong County in the province as the observation point to test the susceptibility of Plasmodium falciparum to chloroquine every two to three years from 1981 to 1991 Sex. The results showed that the resistance of Plasmodium falciparum to chloroquine decreased gradually after stopping the use of chloroquine, and the resistance rate measured by in vitro method decreased from 97.9% in 1981 to 60.9% in 1991 (P <0.001), completely The mean dose of inhibition of schizont formation decreased from 10.46 pmol / μl in 1981 to 3.02 pmol / μl in 1991 (P <0.001), requiring a large dose (6.4 pmol / μl) to completely inhibit schizont formation The proportion of cases decreased from 83.3% in 1981 to 17.4% in 1991 (P <0.001), while the proportion of cases that could be suppressed at low doses (1.6 pmol / μl) increased from 4.2% in 1981 to 1991 Of 60.8% (P <0.001). The resistance rate measured by the in vivo method decreased from 84.2% in 1981 to 40% in 1991 (P <0.001), and the proportion of RII and RIII-resistant cases dropped from 59.4% in 1981 to 1991 37.5% (0.02> P> 0.01).