【摘 要】
：
Dear Editor,rnNoroviruses are positive-sense,single-stranded RNA viruses belonging to Caliciviridae and account for more than 50％ of all acute gastroenteritis (AGE) outbreaks worldwide and cause an estimated 200,000 deaths per year among children ＜ 5 year
【机 构】
：
National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and P
论文部分内容阅读
Dear Editor,rnNoroviruses are positive-sense,single-stranded RNA viruses belonging to Caliciviridae and account for more than 50％ of all acute gastroenteritis (AGE) outbreaks worldwide and cause an estimated 200,000 deaths per year among children ＜ 5 years of age,primarily in developing countries (Hall et al.2012;Glass et al.2009).The norovirus genome contains three open reading frames (ORFs).ORF1 encodes nonstructural proteins,including an RNA-dependent RNA polymerase (RdRp),while ORF2 and ORF3 encode the major (VP1) and minor (VP2) structural proteins,respectively.Based on the sequences of their VP1 genes,noroviruses are classified into at least seven genogroups (GI-GVII) and more than 30 genotypes (Vinjé 2015).GI and GII viruses are responsible for most human infections.
其他文献
Dear Editor,The fall armyworm,Spodoptera frugiperda (Lepidoptera:Noctuidae),a highly agricultural destructive pest of cereals,is originally rampant in tropical and subtropical America (Kenis et al.2019).The caterpillars of this moth feed on more than 350
RNA granules are cytoplasmic,microscopically visible,non-membrane ribo-nucleoprotein structures and are important posttranscriptional regulators in gene expression by controlling RNA translation and stability.TIA/G3BP/PABP-specific stress granules (SG) an
Cellular microRNAs (miRNAs) have been shown to modulate HCV infection via directly acting on the viral genome or indirectly through targeting the virus-associated host factors.Recently we generated a comprehensive map of HCV-miRNA interactions through gen
During human immunodeficiency virus (HIV) infection,type Ⅰ interferon (IFN-Ⅰ) signaling induces an antiviral state that includes the production of restriction factors that inhibit virus replication,thereby limiting the infection.As seen in other viral inf
Enteric viruses are the most common cause of acute gastroenteritis (AGE) in young children and a significant public health problem globally.Hospital admissions of children under 5 years of age with diarrhea are primarily associated with group A rotavirus
Dear Editors,rnThe coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, broke out in early December 2019 has escalated into a global pandemic (Lai et al.2020).Till the May 20th 2020, more than 4,700,000 people were infected and the number is still i
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever disease caused by SFTSV,a newly discovered phlebovirus that is named after the disease.Currently,no effective vaccines or drugs are available for use against SFTSV infecti
Stress granules (SGs) are intracellular granules formed when cellular translation is blocked and have been reported to be involved in a variety of viral infections.Our previous studies revealed that SGs are involved in the coxsackievirus B (CVB) infection
Dear Editor,rnSince the first outbreak in Brazil in 2015,Seneca Valley virus (SVV) associated with porcine idiopathic vesicular disease,has shown increasing geographic distribution.Cases of SVV have been reported from several countries including the Unite