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解偶联蛋白(UCP)属于线粒体载体蛋白超家族成员,UCP1的生理学功能是调节适应性产热导致的质子渗漏。后来又陆续发现了许多UCP1的同源物,其中最重要的两种是UCP2和UCP3。UCP2在1997年被克隆,近来有研究表明,UCP2在2型糖尿病等疾病中起了重要的调节作用。本组从UCP家族的概述及UCP2与2型糖尿病的相关性两方面进行综述。认为UCP2可以负调节胰岛素的分泌,它通过调节细胞内线粒体的质子渗漏,从而降低细胞内ATP合成,使细胞分泌的胰岛素减少,是一个重要的β细胞调节分子,在糖尿病的发病过程中起到重要的作用,对2型糖尿病的防治有重要意义。
Uncoupling proteins (UCPs) belong to the mitochondrial carrier protein superfamily member and the physiological function of UCP1 is to regulate proton leakage caused by adaptive thermogenesis. Later, many UCP1 homologues were discovered one after another, the two most important ones being UCP2 and UCP3. UCP2 was cloned in 1997, and recent studies have shown that UCP2 plays an important regulatory role in diseases such as type 2 diabetes. The group reviewed the UCP family overview and the correlation between UCP2 and type 2 diabetes mellitus. It is believed that UCP2 can negatively regulate the secretion of insulin. It is an important β-cell regulator that regulates the synthesis of intracellular ATP by regulating the proton leakage of mitochondria in cells. It plays an important role in the pathogenesis of diabetes To the important role of prevention and treatment of type 2 diabetes is of great significance.