论文部分内容阅读
大量关于褪黑激素(一种认为有睡眠促进功能的激素)随年龄增加而降低的报道,使人联想到以褪黑激素替代疗法医治老年人睡眠障碍性疾病。本文目的旨在重新评价非用药健康成年人随年龄增长内源性血浆褪黑激素(PM)昼夜节律的变化。自1990～1996年,作者对101名青年男性、19名年龄超过65岁的老年男性及24名老年女性的PM状况进行了研究,被研究者无躯体及精神性疾病,无睡眠障碍,未服用任何药物。在这最初的144名参入者中,12名(老年男、女性各4名、青年男性2名)因各种原因未包括在此分析中。目前分析的PM数据分别来
A number of reports of melatonin, a hormone known to have sleep-promoting effects, decreasing with age are reminiscent of melatonin replacement therapy for the elderly with sleep-disorder disorders. The purpose of this paper is to re-evaluate the changes in the circadian rhythm of endogenous plasma melatonin (PM) with increasing age in healthy, non-medicated adults. From 1990 to 1996, the authors studied the PM status of 101 young men, 19 older men over 65, and 24 elderly women who had no physical or mental illness, no sleep disorders, and no taking Any medicine. Of the first 144 participants, 12 (4 for older men and 4 for women, and 2 for young men) were not included in this analysis for various reasons. The current analysis of the PM data separately